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KMID : 1094020230400030225
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Journal of Veterinary Clinics
2023 Volume.40 No. 3 p.225 ~ p.229
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Quantitative Analysis of Cerebellar Cortical Degeneration Using MRI in Dogs
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Lee Seok-Min
Lee A-Rim
Lee Young-Won
Choi Ho-Jung
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Abstract
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In three dogs showing cerebellar ataxia, the onset of clinical signs varied from a young age of five months to age 13 years. Qualitative magnetic resonance imaging (MRI) revealed various degrees of cerebellar atrophy, and a tentative diagnosis of cerebellar cortical degeneration was made. Quantitative analysis using the brainstem to the cerebellar cross-sectional area ratio (BS:CBM ratio) and T2-signal intensity histograms were obtained to perform an objective evaluation. These techniques have the advantage of being easy and fast to evaluate. These quantitative analyses revealed the severity of cerebellar cortical degeneration in the three dogs as mild, moderate, and severe. Dogs 2 and 3 were identified as abnormal on the relative cerebrospinal fluid (CSF) space using T2-signal intensity histograms but were normal on the BS:CBM ratio. This suggests that the T2-signal intensity histograms may have higher sensitivity than BS:CBM ratio.
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KEYWORD
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cerebellar atrophy, cerebellar abiotrophy, dog, T2-signal intensity histogram, brainstem to cerebellum corss-sectional area
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